Advances in Molecular Oncology: Edited under the auspices of by Maren Oehlmann, Cathal Mahon, Heinz-Peter Nasheuer (auth.),

By Maren Oehlmann, Cathal Mahon, Heinz-Peter Nasheuer (auth.), Director Fabrizio d'Adda di Fagagna, Director Susanna Chiocca, Director Fraser McBlane, Director Ugo Cavallaro (eds.)

Proceedings of the second Annual IFOM-IEO assembly on melanoma. this can be a new assembly, it has approximately two hundred attendees from Australia, Austria, Belgium, Brazil, Canada, England, France, Germany, Greece, eire, Italy, Japan, Netherlands, Spain, Sweden, Switzerland, and the USA.

The 2d IFOM-IEO foreign assembly on melanoma will offer a discussion board during which the world’s prime melanoma researchers and younger scientists will talk about the most recent advances in molecular oncology. The effect of modern breakthroughs in uncomplicated examine and of rising applied sciences on molecular drugs in melanoma can be highlighted.

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Additional info for Advances in Molecular Oncology: Edited under the auspices of the European Institute of Oncology (IEO) and The FIRC Institute of Molecular Oncology Foundation (IFOM)

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64, 4736–4743. E. (2005). Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122, 553–563. A. (2005). Oncogeneinduced senescence as an initial barrier in lymphoma development. Nature 436, 660–665. , and Agami, R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550–553. , and Stoter, G. (1998). Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines. Br. J. Cancer 77, 1562–1567.

2. , 2005). Therefore, the miRNAmediated circumvention of the activation of p53 can in principle be obtained at a level upstream of p53, on p53 itself, or downstream. To shed more light on this aspect, we examined the effect of miR-372&3 expression on p53 activation in response to oncogenic stimulation. We used for this experiment A 100 bp cluster 372mut 371&2 373 Y ctrl P cluster 373 372mut 371&2 P Y ctrl clusler 371&2 372mut Y ctrl P ctrl miR-Vec 373mut miR-Vec cluster miR-Vec 372mut probe Cyclo Protected miR probe mature miRs Probes: 371 372 ϩRASV12 B 6 Cumulative growth advantage 373 4 12 miR-Vec ctrl miR-Vec 371&2 miA-Vec ctrl miR-Vec 371&2 miR-Vec 372 mutant miR-Vec 373 miR-Vec 373 mutant pRS 53kd pRS 14kd 10 miR-Vec 372 mutant miR-Vec 373 miR-Vec 373 mutant pRS 53kd pRS 14kd 8 6 2 4 2 0 days 0 0 5 10 0 5 10 FIGURE 3.

2005). Oncogeneinduced senescence as an initial barrier in lymphoma development. Nature 436, 660–665. , and Agami, R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550–553. , and Stoter, G. (1998). Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines. Br. J. Cancer 77, 1562–1567. P. (2004). MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83–86. , et al. (2005). Crucial role of p53-dependent cellular senescence in suppression of Ptendeficient tumorigenesis.

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