By Ivana Pantelic
The on-going ‘green’ development within the own care coupled with international environmental matters, position natural-origin, biodegradable and skin-friendly surfactants corresponding to alkyl polyglucosides (APGs) in excessive call for. After winning use in cosmetics, enough information has been bought to welcome a few sugar emulsifiers into the sector of drug dosage. Alkyl Polyglucosides provides a accomplished compendium which publications a researcher from the APG-related preformulation levels to formula processing, together with the research of varied APG-stabilized platforms epidermis functionality. This publication introduces numerous APG representatives, their merits when it comes to convinced traditional surfactants, physicochemical and interfacial houses, attainable interplay with commonplace components and numerous characterization options vital for the evaluate of colloidal platforms. the 1st bankruptcy introduces alkyl polyglucosides, by means of chapters on their homes, behaviour, an summary of the patent safeguard mechanisms and directions for filing patent purposes. ultimately, a end surveys overseas patent purposes related to APGs.
- introduces the sector of alkyl polyglucoside emulsifiers, directory the entire modern and newly synthesized APG emulsifiers
- provides specified info on numerous facets of APG-based constructions
- reveals strength of APG-stabilized autos as potential supply structures utilizing numerous version medicines and beauty actives
- includes an up to date evaluate of study carried out within the box of APGs, facilitating destiny preformulation and formula reviews for researchers
- offers a concise and useful compendium of characterization innovations
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Additional info for Alkyl polyglucosides : from natural-origin surfactants to prospective delivery systems
2013), indicating a certain percentage of water entrapped between the lamellae as interlamellar or fixed (‘depot’) water. , 2013). , 2013). Namely, it is proposed that, compared with binary systems, in ternary systems the presence of a third (oil) component results in, along with ordered lamellar gel and liquid crystalline phases within the continuous phase of the emulsion system, an additional phase of liquid crystals, organized in the form of layers surrounding the oil droplets. It is possible that during emulsification a certain insertion of medium-chain triglyceride alkyl chains (C8–C12) as oil phase occurs, creating a new, disordered liquid crystalline structure of lamellar type, situated either at the border of oil droplets or randomly widespread towards the continuous phase, together with the previously described gel phase.
10). 10 Polarization micrographs of investigated cream samples with the APG-mixed emulsiﬁer comprising Hydroxystearyl alcohol and Hydroxystearyl glucoside and different oil phases: (a) Caprylic/Capric Triglyceride oil; (b) Jojoba oil; (c) Hazelnut oil that lyotropic liquid crystalline phase behaviour is influenced by the structure of the surfactant. , 2011a) revealed that the APG mixed emulsifier Cetearyl glucoside and Coco glucoside, provides a physically stable emulsion with no visible anisotropic structures.
1 Critical micelle concentration and micelle shape When discussing surfactant behaviour in solution, the keystone is research into their critical micelle concentration (CMC). It is well known that CMC is the concentration above which monomeric surfactant molecules abruptly assemble into aggregates called micelles (Hait and Moulik, 2002). The CMC is useful as it reveals the propensity of the surfactant to assemble in water. Surface tension is probably the most common tool for CMC determination. Prior to the point at which the CMC is reached, the surfactant molecules position themselves at the air/water interface and thus lower the surface tension.