By Jean-Pierre Lepoittevin, David A. Basketter, An Goossens, Ann-Therese Karlberg, R.J.G. Rycroft
Allergic touch Dermatitis offers all updated chemical and physio-chemical techniques for the research and knowing of allergic touch dermatitis (ACD). The ebook covers all facets of ACD - epidermis penetration and metabolism, id of sensitizers and hapten-protein interplay, together with new options of accelerating significance resembling molecular attractiveness and quantitative structure-activity relationships. moreover, accomplished references are supplied, making this the main entire on hand text-book for dermatologists.
Allergic touch Dermatitis reaches an equilibrium among basic innovations and scientific functions and hence provides a vital guide to dermatologists, allergologists, biochemists and toxicologists.
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Extra resources for Allergic Contact Dermatitis: The Molecular Basis
The amount of the solvent must be kept below the level at which the sample was applied. Owing to capillary forces, the eluent is drawn up over the plate. The chemical nature of the components in the applied sample and competition between the silica and the eluent to attract the components will determine how much these will move on the plate, giving different retardation factors (= RF-values) for the components. The RF-value is the ratio of the distance traveled by the center of a component spot to the distance simultaneously traveled by the eluent (see below, Sect.
We will consider three main types of heterolytic reaction encountered in the phenomena of contact allergy: 1. Nucleophilic substitution on a saturated carbon 2. Nucleophilic substitution on an unsaturated carbon 3. 2 Nucleophilic Substitution on a Saturated Center Nucleophilic substitution on a saturated carbon involves the attack by an electron-rich nucleophile on an electron-deficient electrophilic center. Since the electrophilic carbon already has four a bonds, a new bond can be formed only if one of the pre-existing a bonds is broken.
NuH Alantolactone ~o Nu Fig. 38. NuH 41 Chemical Basis Fig. 39. Generation of free radicals x + V The bond can be formed in two ways: - By the sharing of two radicals to form a shared doublet, as in the mechanism for the formation of a covalent bond (Fig. 40). Note that, in the case of radical reactions, bond formation is represented schematically by single-barbed arrows, representing displacement of a single electron. - By the reaction of a radical and a molecule to give a new radical and a new molecule by a substitution or addition reaction (Fig.